DANA FARBER/BOSTON CHILDREN’S CANCER AND BLOOD DISORDER CENTER

This study funded by IFF is focused on identifying new therapeutic targets to treat Pediatric Low-Grade Gliomas (PLGGs).  Children diagnosed with PLGGs face a chronic illness, characterized by multiple episodes of tumor recurrence.  Although children with PLGGs are likely to be long-term survivors, many are burdened with devastating life-long morbidities from their tumor and treatments.

Dana Farber’s recent findings that many PLGGs are associated with fusions of the MYB and QKI genes hold great significance as it identifies a recurrent driver alteration for the first time in angiocentric gliomas and other diffuse gliomas.  Uncovering the mechanisms by which this contributes to tumor formation will allow researchers to develop genetically defined models and determine therapeutic strategies that can be translated quickly into the clinic. This could lead to targeted therapies that can improve their outcomes and quality of life.

More on Dana Farber / Boston Children’s Cancer and Blood Disorders Center here: Brain Tumor – Pediatric Cancer Treatment – Dana-Farber Cancer Institute | Boston, MA

 

Our Research Partnerships

To date, Ian’s Friends Foundation has committed millions of dollars toward pediatric brain tumor research at the cutting-edge research institutions listed below.

Long-term goal is to improve understanding of tumor metabolism to design more effective therapies.
Long-term goal is to improve understanding of tumor metabolism to design more effective therapies.
New biorepository will provide the technology to grow and store cancer cells for use in brain tumor research.
New biorepository will provide the technology to grow and store cancer cells for use in brain tumor research.
Together, these Atlanta institutions pioneer the use of nanotechnology to gauge tumor size, stop tumor growth, and shrink tumors.
Together, these Atlanta institutions pioneer the use of nanotechnology to gauge tumor size, stop tumor growth, and shrink tumors.
Research focused on uncovering the mechanisms by which gene fusions contribute to tumor formation in pediatric low grade gliomas.
Research focused on uncovering the mechanisms by which gene fusions contribute to tumor formation in pediatric low grade gliomas.
Objective is to determine if an electrical stimulations regimen can arrest the division of dividing brain tumor cells.
Objective is to determine if an electrical stimulations regimen can arrest the division of dividing brain tumor cells.
Working to find biomarkers for brain tumors to make the diagnosis of tumor types easier, track their growth or even, no recurrence.
Working to find biomarkers for brain tumors to make the diagnosis of tumor types easier, track their growth or even, no recurrence.
Research focused on proteins which are active in pediatric low-grade gliomas. From this research, NYU hopes to better select molecular targeted drugs directed at these pathways.
Research focused on proteins which are active in pediatric low-grade gliomas. From this research, NYU hopes to better select molecular targeted drugs directed at these pathways.
Research focused on using new brain imaging techniques to improve diagnosis, prognosis and treatment of pediatric brain tumors.
Research focused on using new brain imaging techniques to improve diagnosis, prognosis and treatment of pediatric brain tumors.
Research establishing the feasibility of using interstitial infusion for treating pediatric brain stem gliomas. FDA approved clinical trial underway.
Research establishing the feasibility of using interstitial infusion for treating pediatric brain stem gliomas. FDA approved clinical trial underway.